Win32/Poweliks.A is a trojan which tries to download other malware from the Internet, and can be controlled remotely.
inetcpl.cplinto the Open field and click OK. This will open Internet Properties (otherwise known as Internet Options).
More recent versions of ESET products include updated modules that help protect against Poweliks infections. It is important that you are running the latest version to ensure maximum protection against this threat.